Ligand id: 9581

Name: ARN-3236

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 75.38
Molecular weight 336.09
XLogP 4.63
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
Inhibition of SIK2 by ARN-3236 interferes with mitotic spindle formation, and this ultimately blocks mitotic progression and triggers apoptotic cell death [3].