Ligand id: 9601

Name: anlotinib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 82.39
Molecular weight 407.16
XLogP 3.48
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
AL3818 is a Phase 3 clinical candidate for sarcoma (see NCT03016819), Phase 2 for hepatocellular carcinoma (NCT02809534) and advanced renal cell carcinoma (NCT02072031), as well as Phase 1/2a for recurrent or metastatic endometrial, ovarian or cervical cancer (NCT02558348). Clinical trials in renal cell carcinoma, non-small cell lung cancer and colorectal cancer are also underway.