clodronic acid   Click here for help

GtoPdb Ligand ID: 9605

Synonyms: Bonefos® | Clasteon ® | clodronate | Loron®
Approved drug Immunopharmacology Ligand
clodronic acid is an approved drug (UK (1999))
Compound class: Synthetic organic
Comment: Clodronic acid is a first generation (non-nitrogenous) bisphosphonate drug. Clinically used drugs can contain sodium clodronate tetrahydrate, sodium clodronate, disodium clodronate tetrahydrate or disodium clodronate.

Kato et al. (2017) report that clodronic acid-mediated inhibition of the vesicular nucleotide transporter (VNUT, SLC17A9) suggests that this drug has potential as a transporter-targeted (and notably, non-opioid) analgesic drug for the treatment of chronic neuropathic and inflammatory pain [1]. In this study clodronic acid was selective for VNUT compared to other vesicular transporters tested.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 134.68
Molecular weight 243.89
XLogP -2.4
No. Lipinski's rules broken 0
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Canonical SMILES ClC(P(=O)(O)O)(P(=O)(O)O)Cl
Isomeric SMILES ClC(P(=O)(O)O)(P(=O)(O)O)Cl
InChI InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)
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Summary of Clinical Use Click here for help
Approved for the management of osteolytic lesions, hypercalcaemia and bone pain associated with skeletal metastases in patients with carcinoma of the breast or multiple myeloma. Also indicated for the maintenance of clinically acceptable serum calcium levels in patients with hypercalcaemia of malignancy initially treated with an intravenous bisphosphonate. Veterinary use only in the US.