Synonyms: Evoxac®
cevimeline is an approved drug (FDA (2000))
Compound class:
Synthetic organic
Comment: Cevimeline is an orally administered cholinergic analogue with parasympathomimetic activity. The INN is a mixture of enantiomers. We show the structure without stereochemistry to represent the mixture.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖![]() View more information in the IUPHAR Pharmacology Education Project: cevimeline |
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No information available. |
Summary of Clinical Use ![]() |
Cevimeline is used in the treatment of dry mouth, especially as associated with Sjögren's syndrome. |
Mechanism Of Action and Pharmacodynamic Effects ![]() |
Cevimeline binds to and activates muscarinic receptors and promotes exocrine secretion of salivary and sweat glands. |
External links ![]() |
For extended ADME data see the following: Drugs.com |