lodoxamide   Click here for help

GtoPdb Ligand ID: 9743

Synonyms: Alomide®
Approved drug Immunopharmacology Ligand
lodoxamide is an approved drug (UK (1991), FDA (1993))
Compound class: Synthetic organic
Comment: Lodoxamide is a mast cell stabilizing anti-inflammatory drug. Clinically administered forms may contain lodoxamide trometamol/tromethamine.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 9
Hydrogen bond donors 4
Rotatable bonds 6
Topological polar surface area 156.59
Molecular weight 310.99
XLogP -0.34
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl
Isomeric SMILES N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl
InChI InChI=1S/C11H6ClN3O6/c12-7-5(14-8(16)10(18)19)1-4(3-13)2-6(7)15-9(17)11(20)21/h1-2H,(H,14,16)(H,15,17)(H,18,19)(H,20,21)
InChI Key RVGLGHVJXCETIO-UHFFFAOYSA-N
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Summary of Clinical Use Click here for help
Lodoxamide is used in opthalmic solutions to treat occular inflammation (keratitis or conjunctivitis) caused by the allergic response.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Lodoxamide inhibits mast cell degranulation thereby reducing the release of histamine, leukotrienes, and other inflammatory mediators involved in hypersensitivity reactions. It also inhibits eosinophil chemotaxis.
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