AZD9567   Click here for help

GtoPdb Ligand ID: 9812

Synonyms: AZD 9567 | AZD-9567 | compound 15 [PMID: 29424542] | example 1 [WO2016046260A1] [2]
PDB Ligand Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: AZD9567 is a synthetic, selective glucocorticoid receptor (GR) partial agonist [1]. It was designed to offer an improved side-effect profile compared to conventional full agonist GR anti-inflammatory dugs. AZD9567 is one of the chemical structures claimed in patent WO2016046260A1 [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 9
Topological polar surface area 77.63
Molecular weight 494.21
XLogP 5.94
No. Lipinski's rules broken 1
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Canonical SMILES CC(C(C(c1ccccc1)Oc1ccc2c(c1)cnn2c1ccc(=O)n(c1)C)NC(=O)C(F)(F)C)C
Isomeric SMILES CC([C@@H]([C@@H](c1ccccc1)Oc1ccc2c(c1)cnn2c1ccc(=O)n(c1)C)NC(=O)C(F)(F)C)C
InChI InChI=1S/C27H28F2N4O3/c1-17(2)24(31-26(35)27(3,28)29)25(18-8-6-5-7-9-18)36-21-11-12-22-19(14-21)15-30-33(22)20-10-13-23(34)32(4)16-20/h5-17,24-25H,1-4H3,(H,31,35)/t24-,25+/m0/s1
No information available.
Summary of Clinical Use Click here for help
AZD9567 has reached Phase 2 clinical trial for rheumatoid arthritis in which it is being compared to prednisolone (see NCT03368235).
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT03368235 Early Phase Study to Assess Efficacy and Safety of AZD9567 Versus Prednisolone in Patients With Rheumatoid Arthritis Phase 2 Interventional AstraZeneca