pamapimod

Ligand id: 9915

Name: pamapimod

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 109.5
Molecular weight 406.15
XLogP 3.16
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Pamapimod reached Phase 2 clinical evaluation as an immunomodulator for rheumatoid arthritis, but development was terminated due to a lack of clinical efficacy, either as a monotherapy, or as an adjunct to methotrexate [1,3].
Mechanism Of Action and Pharmacodynamic Effects
The ratinale for inhibiting p38 MAPK as a novel apporach for the treatment of rheumatoid arthritis is discussed in [5] and [2].