Ligand id: 10091

Name: CRX-555

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 21
Hydrogen bond donors 6
Rotatable bonds 73
Topological polar surface area 315.96
Molecular weight 1402.97
XLogP 22.5
No. Lipinski's rules broken 4

Molecular properties generated using the CDK

Immunopharmacology Comments
Synthetic TRL4 agonists have been evaluated for potential adjuvant and immunoeffector functions, and TLR4 antagonists for anti-inflammatory uses in autoimmune diseases [1-3,5-7]. The most recent advances in this field are reviewed by Zaffaroni and Peri (2018) [10].