CRX-555

Ligand id: 10091

Name: CRX-555

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 21
Hydrogen bond donors 6
Rotatable bonds 73
Topological polar surface area 315.96
Molecular weight 1402.97
XLogP 22.5
No. Lipinski's rules broken 4

Molecular properties generated using the CDK

References
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TLR4 agonists as immunomodulatory agents.
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Synthetic toll-like receptor 4 agonists stimulate innate resistance to infectious challenge.
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A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease.
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Aminoalkyl glucosamine phosphate compounds for treating autoimmune diseases.
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Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors.
Patent number: US6303347B1. Assignee: Corixa Corp.. Priority date: 08/05/1997. Publication date: 16/10/2001.
9. Stöver AG, Da Silva Correia J, Evans JT, Cluff CW, Elliott MW, Jeffery EW, Johnson DA, Lacy MJ, Baldridge JR, Probst P et al.. (2004)
Structure-activity relationship of synthetic toll-like receptor 4 agonists.
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Recent advances on Toll-like receptor 4 modulation: new therapeutic perspectives.
Future Med Chem, 10 (4): 461-476. [PMID:29380635]