TUG-1375   Click here for help

GtoPdb Ligand ID: 10107

Synonyms: compound 31 [PMID: 30247908] | TUG1375
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: TUG-1375 was designed as a selective free fatty acid receptor 2 (FFA2/GPR43) agonist, as a pharmacological tool that is suitable for the study of FFA2 receptor function in vitro and in vivo [1]. FFA2 is known to be involved in regulation of metabolism, appetite, fat accumulation and inflammatory responses.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 108.94
Molecular weight 442.08
XLogP 4.89
No. Lipinski's rules broken 0
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Canonical SMILES O=C(N1C(CSC1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C
Isomeric SMILES O=C(N1[C@H](CS[C@H]1c1ccccc1Cl)C(=O)O)c1ccc(cc1)c1c(C)noc1C
InChI InChI=1S/C22H19ClN2O4S/c1-12-19(13(2)29-24-12)14-7-9-15(10-8-14)20(26)25-18(22(27)28)11-30-21(25)16-5-3-4-6-17(16)23/h3-10,18,21H,11H2,1-2H3,(H,27,28)/t18-,21+/m1/s1
Immunopharmacology Comments
FFA2 is highly expressed on neutrophils [2] and may play a role in diseases that are associated with a dysfunctional neutrophil response (e.g. inflammatory bowel disease). As a result FFA2 is being investigated as a novel drug target for the treatment of such inflammatory diseases (as well as for metabolic diseases such as type 2 diabetes) [3]. TUG-1375 induces mobilisation of human neutrophils in vitro, at a level similar to the FFA2 endogenous ligand propionate [1].