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Synonyms: R-411 | RO-0272441
Compound class: Synthetic organic
Comment: Valategrast (RO-0272441) is an orally available, small molecule α4 integrin inhibitor that was developed by Roche . It is active at α4β1 and α4β7 integrins.
|Valategrast was designed to reduce excessive and pathological leukocyte infiltration into tissues, as a mechanism to treat inflammatory diseases, including asthma and chronic obstructive pulmonary disease.|