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Synonyms: R-411 | RO-0272441
Compound class: Synthetic organic
Comment: Valategrast (RO-0272441) is an orally available, small molecule α4 integrin inhibitor that was developed by Roche . It is active at α4β1 and α4β7 integrins.
1. Hijazi Y, Welker H, Dorr AE, Tang JP, Blain R, Renzetti LM, Abbas R. (2004)
Pharmacokinetics, safety, and tolerability of R411, a dual alpha4beta1-alpha4beta7 integrin antagonist after oral administration at single and multiple once-daily ascending doses in healthy volunteers.
J Clin Pharmacol, 44 (12): 1368-78. [PMID:15545307]
2. Woodside DG, Vanderslice P. (2008)
Cell adhesion antagonists: therapeutic potential in asthma and chronic obstructive pulmonary disease.
BioDrugs, 22 (2): 85-100. [PMID:18345706]