Ligand id: 4218

Name: iberiotoxin

Structure and Physico-chemical Properties

2D Structure
Immunopharmacology Comments
Iberiotoxin is somewhat selective for KCa1.1 channels that associate with β3b regulatory subunits that are expressed by invasive RA fibroblast-like synoviocytes [4], a cell-type involved in rheumatoid arthritis (RA) progression [5]. This selectivity should spare the CNS KCa1.1 β4 channels, and limit the CNS side-effects associated with non-selective inhibitors like paxilline. Efficacy of iberiotoxin-mediated KCa1.1 channel blockade on fibroblast-like synoviocytes in rodent models of RA suggests this molecular mechanism as a novel approach for the development of RA therapeutucs [5].