Ligand id: 4968

Name: IFN-γ

Species: Human

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Immunopharmacology Comments
IFN-γ is produced by Th1 cells. It binds the IFN-γ receptor (IFNGR), a dimeric receptor that consists of protein chains encoded by the IFNGR1 and IFNGR2 genes. IFN-γ induces expression of genes with gamma interferon activation site (GAS) elements. Innate lymphoid ILC1s release IFN-γ in inflamaed conditions
Immunopharmacology Disease
Disease X-Refs Comment References
Chronic granulomatous disease Disease Ontology: DOID:3265
Orphanet: ORPHA379
Approved therapy for chronic granulomatous disease.