IFN-γ

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Ligands
IFN-γ (Human)

GtoPdb Ligand ID: 4968

Synonyms: Actimmune® | immune interferon | interferon gamma

IFN-γ is an approved drug (FDA (1999))

Compound class: Endogenous peptide in human, mouse or rat

Comment: IFN-γ is a type II interferon. It is biologically active as a homodimer.

Species: Human

View more information in the IUPHAR Pharmacology Education Project: interferon-gamma (ifn-γ)

Summary
Biological activity
Clinical data
References
Structure
Similar ligands
Immunopharmacology

Immunopharmacology Comments
IFN-γ is produced by Th1 cells. It binds the IFN-γ receptor (IFNGR), a dimeric receptor that consists of protein chains encoded by the IFNGR1 and IFNGR2 genes. IFN-γ induces expression of genes with gamma interferon activation site (GAS) elements. Innate lymphoid ILC1s release IFN-γ in inflamaed conditions

Immunopharmacology Comments

IFN-γ is produced by Th1 cells. It binds the IFN-γ receptor (IFNGR), a dimeric receptor that consists of protein chains encoded by the IFNGR1 and IFNGR2 genes. IFN-γ induces expression of genes with gamma interferon activation site (GAS) elements. Innate lymphoid ILC1s release IFN-γ in inflamaed conditions

Immunopharmacology Disease
Disease	X-Refs	Comment	References
Chronic granulomatous disease	Disease Ontology: DOID:3265 Orphanet: ORPHA379	Approved therapy for chronic granulomatous disease.