IFN-γ   Click here for help

GtoPdb Ligand ID: 4968

Synonyms: Actimmune® | immune interferon | interferon gamma
Approved drug Immunopharmacology Ligand
IFN-γ is an approved drug (FDA (1999))
Comment: IFN-γ is a type II interferon. It is biologically active as a homodimer.
Species: Human
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: interferon-gamma (ifn-γ)

Immunopharmacology Comments
IFN-γ is produced by Th1 cells. It binds the IFN-γ receptor (IFNGR), a dimeric receptor that consists of protein chains encoded by the IFNGR1 and IFNGR2 genes. IFN-γ induces expression of genes with gamma interferon activation site (GAS) elements. Innate lymphoid ILC1s release IFN-γ in inflamaed conditions
Immunopharmacology Disease
Disease X-Refs Comment References
Chronic granulomatous disease Disease Ontology: DOID:3265
Orphanet: ORPHA379
Approved therapy for chronic granulomatous disease.