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Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-15 and IL-2 are cytokines that share common biological effects, but also exhibit distinct, and sometimes competing, functions .
Nektar Therapeutics is developing a long-acting polymer-engineered (e.g. PEGylated) IL-15 conjugate, code named NKTR-255 (structure not disclosed), as a potential immuno-oncology agent- see their patent US20170035898 . The conjugate has been optimised for binding to the IL-15Rα subunit and improved plasma and tumour exposure compared to native IL-15. This agent is in preclinical evaluation (August 2017).
Calypso Biotech have an anti-IL-15 monoclonal antibody named CALY-002 in their development pipeline. CALY-002 has potential for the treatment of refractory celiac disease and other inflammatory conditions at mucosal interfaces within the gastro-intestinal tract (e.g. eosinophilic esophagitis) . The EMA granted CALY-002 orphan drug designation for the treatment of eosinophilic esophagitis in 2016 .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|IL-15 is a cytokine mainly expressed by monocytes, dendritic cells and epithelial cells. It interacts with components of the IL-2 receptor despite having no sequence homology with IL-2 , and is markedly important in the gastrointestinal tract where it controls the homeostasis and activation of T, B, and NK cells. IL-15 produced by activated monocytes/macrophages is involved in regulation of human NK cells and is particularly vital for the survival of CD8+ memory T cells (essential for maintenance of responses to invading pathogens) . IL-15 has been identied as a promising candidate for use as an immuno-oncology therapeutic, and engineered long-acting IL-15 conjugates are in development. Anti-IL-15 mAbs are in development for anti-inflammatory potential [3,6].|