naproxen   

GtoPdb Ligand ID: 5230

Synonyms: (S)-naproxen | Aleve® | Naprosy®
naproxen is an approved drug (FDA (1976))
Compound class: Synthetic organic
Comment: Naproxen is one of the 2-arylpropionic acid ('profen') family of nonsteroidal anti-inflammatory drugs (NSAIDs), like ibuprofen.
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2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 46.53
Molecular weight 230.09
XLogP 2.84
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES COc1ccc2c(c1)ccc(c2)C(C(=O)O)C
Isomeric SMILES COc1ccc2c(c1)ccc(c2)[C@@H](C(=O)O)C
InChI InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1
InChI Key CMWTZPSULFXXJA-VIFPVBQESA-N
Immunopharmacology Disease
Disease X-Refs Comment References
Gout Disease Ontology: DOID:13189
Approved NSAID used for acute gout.
Osteoarthritis Disease Ontology: DOID:8398
Approved NSAID used for many inflammatory conditions including OA.
Rheumatoid arthritis Disease Ontology: DOID:7148
OMIM: 180300
Approved NSAID used for many inflammatory conditions including RA.
Ankylosing spondylitis Disease Ontology: DOID:7147
Approved NSAID used for ankylosing spondylitis.