Ligand id: 5483

Name: gabapentin

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View more information in the IUPHAR Pharmacology Education Project: gabapentin

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 63.32
Molecular weight 171.13
XLogP 1.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Comments
Mouse studies using models of colonic hypersensitivity suggest some potential for gabapentin as a treatment for chronic abdominal pain and moderate intestinal inflammation [9]. Topically administered gabapentin is also reported to ameliorate ocular inflammation in vitro and in vivo (in rabbit studies) [1].