IKK-2 inhibitor IV

Ligand id: 5986

Name: IKK-2 inhibitor IV

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 126.45
Molecular weight 279.05
XLogP 0.79
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Comments
IKK2 is a protein subunit of the IκB kinase (IKK). Inhibition of IKK and IKK-related kinases has been investigated as an intervention point for the treatment of inflammatory diseases (and cancer) [3].