IKK-2 inhibitor IV

Ligand id: 5986

Name: IKK-2 inhibitor IV

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 126.45
Molecular weight 279.05
XLogP 0.79
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
Janus kinase 1 nd/JAK1 Hs Inhibitor Inhibition 5.4
tyrosine kinase non receptor 2 ACK1/ACK1 Hs Inhibitor Inhibition 5.6 10.0 2.0
tyrosine kinase 2 nd/TYK2 Hs Inhibitor Inhibition 6.3
Janus kinase 2 JAK2/JAK2 Hs Inhibitor Inhibition 7.2 4.0 0.0
inhibitor of nuclear factor kappa B kinase subunit beta IKKβ/IKKb(IKBKB) Hs Inhibitor Inhibition 9.0 12.0 8.0
fms related tyrosine kinase 3 Flt3/FLT3 Hs Inhibitor Inhibition 13.9 22.0 3.0
NUAK family kinase 1 ARK5/ARK5(NUAK1) Hs Inhibitor Inhibition 17.2 29.0 13.0
ret proto-oncogene Ret/RET Hs Inhibitor Inhibition 18.4 30.0 1.0
mitogen-activated protein kinase kinase kinase 9 MLK1/MLK19MAP3K90 Hs Inhibitor Inhibition 22.6 9.0 1.0
aurora kinase B Aurora-B/Aurora B Hs Inhibitor Inhibition 22.7 1.0 2.0
Displaying the top 10 targets  View all targets in screen »