Ligand id: 6476

Name: alvelestat

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 123.81
Molecular weight 545.13
XLogP 4.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Disease
Disease X-Refs Comment References
Graft versus host disease A Phase 2 clinical candidate for bronchiolitis obliterans syndrome resulting from chronic GVHD.
Chronic obstructive pulmonary disease Disease Ontology: DOID:3083
A Phase 2 clinical candidate for COPD.
Diabetes mellitus, noninsulin-dependent; NIDDM Disease Ontology: DOID:9352
OMIM: 125853
A Phase 2 clinical candidate predicted to exhibit a useful effect on T2D-associated inflammation.