Ligand id: 6476

Name: alvelestat

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 123.81
Molecular weight 545.13
XLogP 4.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Andersson, Marjana et al.. (2007)
2-Pyridone Derivatives As Neutrophil Elastase Inhibitors And Their Use.
Patent number: US20070203129. Assignee: AstraZeneca. Priority date: 15/09/2004. Publication date: 30/08/2007.
2. Stevens T, Ekholm K, Gränse M, Lindahl M, Kozma V, Jungar C, Ottosson T, Falk-Håkansson H, Churg A, Wright JL et al.. (2011)
AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase.
J. Pharmacol. Exp. Ther., 339 (1): 313-20. [PMID:21791628]