GtoPdb Ligand ID: 759

Comment: CCL7 is a CC family chemokine, most closely related to CCL2.
Species: Human
Immunopharmacology Comments
CCL7 acts via the chemokine receptors CCR1, CCR2, CCR3 and CCR6. to recruit monocytes to sites of inflammation. It has regulatory action vs. macrophages. MMP2-catalysed cleavage of CCL7 creates a peptide with chemokine receptor antagonist activity that dampens inflammation [6].