CCL7   Click here for help

GtoPdb Ligand ID: 759

Immunopharmacology Ligand
Comment: CCL7 is a CC family chemokine, most closely related to CCL2.
Species: Human
Click here for help
Immunopharmacology Comments
CCL7 acts via the chemokine receptors CCR1, CCR2, CCR3 and CCR6. to recruit monocytes to sites of inflammation. It has regulatory action vs. macrophages. MMP2-catalysed cleavage of CCL7 creates a peptide with chemokine receptor antagonist activity that dampens inflammation [6].