CCL7   Click here for help

GtoPdb Ligand ID: 759

Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL7 is a CC family chemokine, most closely related to CCL2.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Chou CC, Fine JS, Pugliese-Sivo C, Gonsiorek W, Davies L, Deno G, Petro M, Schwarz M, Zavodny PJ, Hipkin RW. (2002)
Pharmacological characterization of the chemokine receptor, hCCR1 in a stable transfectant and differentiated HL-60 cells: antagonism of hCCR1 activation by MIP-1beta.
Br J Pharmacol, 137 (5): 663-75. [PMID:12381680]
2. Coulin F, Power CA, Alouani S, Peitsch MC, Schroeder JM, Moshizuki M, Clark-Lewis I, Wells TN. (1997)
Characterisation of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines.
Eur J Biochem, 248 (2): 507-15. [PMID:9346309]
3. Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS. (1996)
Cloning, expression, and characterization of the human eosinophil eotaxin receptor.
J Exp Med, 183 (5): 2349-54. [PMID:8642344]
4. Habasque C, Aubry F, Jégou B, Samson M. (2002)
Study of the HIV-1 receptors CD4, CXCR4, CCR5 and CCR3 in the human and rat testis.
Mol Hum Reprod, 8 (5): 419-25. [PMID:11994538]
5. Lüttichau HR, Clark-Lewis I, Jensen PØ, Moser C, Gerstoft J, Schwartz TW. (2003)
A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6.
J Biol Chem, 278 (13): 10928-33. [PMID:12554737]
6. McQuibban GA, Gong JH, Tam EM, McCulloch CA, Clark-Lewis I, Overall CM. (2000)
Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3.
Science, 289 (5482): 1202-6. [PMID:10947989]
7. Napier C, Sale H, Mosley M, Rickett G, Dorr P, Mansfield R, Holbrook M. (2005)
Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human.
Biochem Pharmacol, 71 (1-2): 163-72. [PMID:16298345]
8. Uguccioni M, Mackay CR, Ochensberger B, Loetscher P, Rhis S, LaRosa GJ, Rao P, Ponath PD, Baggiolini M, Dahinden CA. (1997)
High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.
J Clin Invest, 100 (5): 1137-43. [PMID:9276730]
9. Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. (1998)
Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
J Biol Chem, 273 (29): 18288-91. [PMID:9660793]