Synonyms: compound 13d [PMID: 25893046]
Compound class:
Synthetic organic
Comment: BMS-681 is an orthosteric antagonist of CC chemokine receptors 2 and 5 (CCR2 and CCR5) [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Immunopharmacology Comments |
CCR2 and its ligands are implicated in numerous inflammatory and neurodegenerative diseases [2]. Drug discovery efforts are targeting the CCR2-chemokine axis for conditions including atherosclerosis, multiple sclerosis, asthma, neuropathic pain, diabetic nephropathy and cancer. |