oleclumab   Click here for help

GtoPdb Ligand ID: 9596

Synonyms: MEDI 9447 | MEDI-9447
Immunopharmacology Ligand
Compound class: Antibody
Comment: Oleclumab (MEDI9447) is a monoclonal antibody targeting the ecto-5'-nucleotidase (CD73), which is being investigated for oncology use [1-2]. Functional studies show that MEDI9447 is a high affinity antagonistic mAb, showing non-competitive inhibition of CD73 hydrolysis of AMP[1]. Two modes of action are suggested: prevention of steric conformational change required for catalytic active state, and inter-CD73 dimer cross-linking.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
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Immunopharmacology Comments
Inhibiting CD73 (ecto-5'-nucleotidase) production of adenosine from 5' AMP is predicted to have immunomodulatory action, by de-repressing immunosurveillance in the tumour microenvironment.