oleclumab   Click here for help

GtoPdb Ligand ID: 9596

Synonyms: MEDI 9447 | MEDI-9447
Immunopharmacology Ligand
Compound class: Antibody
Comment: Oleclumab (MEDI9447) is a monoclonal antibody targeting the ecto-5'-nucleotidase (CD73), which is being investigated for oncology use [1-2]. Functional studies show that MEDI9447 is a high affinity antagonistic mAb, showing non-competitive inhibition of CD73 hydrolysis of AMP[1]. Two modes of action are suggested: prevention of steric conformational change required for catalytic active state, and inter-CD73 dimer cross-linking.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
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1. Geoghegan JC, Diedrich G, Lu X, Rosenthal K, Sachsenmeier KF, Wu H, Dall'Acqua WF, Damschroder MM. (2016)
Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action.
MAbs, 8 (3): 454-67. [PMID:26854859]
2. Hay CM, Sult E, Huang Q, Mulgrew K, Fuhrmann SR, McGlinchey KA, Hammond SA, Rothstein R, Rios-Doria J, Poon E et al.. (2016)
Targeting CD73 in the tumor microenvironment with MEDI9447.
Oncoimmunology, 5 (8): e1208875. [PMID:27622077]