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Compound class: Synthetic organic
Comment: PF-04957325 is a selective inhibitor of PDE8  that is a useful chemical probe for studying the biological function of PDE8. It is compound 1-38 in patent WO2016030345 .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Pharmacological inhibition of PDE8 with the selective inhibitor PF-04957325 regulates CD4+ T cell motility (by disrupting T effector cell adhesion and migration) through the PDE8A-Raf-1 kinase signaling complex . This work suggests that PDE8 inhibitors, or PDE8A-Raf-1 kinase complex disruptors may hold potential value for the control of T cell-mediated inflammation.|