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Compound class: Synthetic organic
Comment: PF-04957325 is a selective inhibitor of PDE8  that is a useful chemical probe for studying the biological function of PDE8. It is compound 1-38 in patent WO2016030345 .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Basole CP, Nguyen RK, Lamothe K, Vang A, Clark R, Baillie GS, Epstein PM, Brocke S. (2017)
PDE8 controls CD4+ T cell motility through the PDE8A-Raf-1 kinase signaling complex.
Cell Signal, 40: 62-72. [PMID:28851628]
2. María del Mar Cuadrado T, Garcia OAM, Oyarzabel SJ, Rabal GMO. (2016)
Products for the treatment and prevention of neurological disorders coursing with a cognition deficit or impairment, and of neurodegenerative diseases.
Patent number: WO2016030345. Assignee: Fundación Para La Investigación Médica Aplicada. Priority date: 26/08/2014. Publication date: 03/03/2016.
3. Maurice DH, Ke H, Ahmad F, Wang Y, Chung J, Manganiello VC. (2014)
Advances in targeting cyclic nucleotide phosphodiesterases.
Nat Rev Drug Discov, 13 (4): 290-314. [PMID:24687066]