Ligand id: 9714

Name: BI-6901

Abbreviated name: BI 6901

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 119.37
Molecular weight 453.18
XLogP 2.82
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Comments
BI-6901 is a CCR10 inhibitor suitable for in vitro and in vivo validation studies. It is highly selective for CCR10 over other GPCRs, including a number of other chemokine receptors, and is efficacious in a murine model of DNFB contact hypersensitivity. BI-6901 inhibits CCL27-mediated chemotaxis of Ba/F3 cells with an IC50 of 1nM [1].