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Synonyms: XP 23829 | XP-23829 | XP23829
Compound class: Synthetic organic
Comment: Tepilamide fumarate (XP23829) is a small-molecule fumaric acid ester prodrug of monomethyl fumarate (MMF). It is being developed by Arbor Pharmaceuticals (formerly XenoPort) as a potential treatment for autoinflammatory diseases.
|The active moeity of this compound, MMF, is an inhibitor of the KEAP1-Nrf2 protein-protein interaction, or functional Nrf2 activator. Compounds exhibiting this mechanism of action have anti-inflammatory and cytoprotective activity.|