Ligand id: 9841

Name: merestinib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 106.31
Molecular weight 552.17
XLogP 6.5
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Immunopharmacology Comments
Several of the targets of merestinib, such as MST1R, AXL, MERTK, MKNK1/2, and TEK, also play a role in immune cell functions, especially myeloid cell functions [2-3]. Of particular interest is the identification of the TAM receptor tyrosine kinases (TYRO3, AXL, and MERTK) as innate immune checkpoints that could be pharmacologically exploited to promote anti-tumoural immunity [1].