merestinib

Ligand id: 9841

Name: merestinib

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 106.31
Molecular weight 552.17
XLogP 6.5
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Akalu YT, Rothlin CV, Ghosh S. (2017)
TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy.
Immunol. Rev., 276 (1): 165-177. [PMID:28258690]
2. Eyob H, Ekiz HA, Derose YS, Waltz SE, Williams MA, Welm AL. (2013)
Inhibition of ron kinase blocks conversion of micrometastases to overt metastases by boosting antitumor immunity.
Cancer Discov, 3 (7): 751-60. [PMID:23612011]
3. Su X, Yu Y, Zhong Y, Giannopoulou EG, Hu X, Liu H, Cross JR, Rätsch G, Rice CM, Ivashkiv LB. (2015)
Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation.
Nat. Immunol., 16 (8): 838-849. [PMID:26147685]
4. Yan SB, Peek VL, Ajamie R, Buchanan SG, Graff JR, Heidler SA, Hui YH, Huss KL, Konicek BW, Manro JR et al.. (2013)
LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models.
Invest New Drugs, 31 (4): 833-44. [PMID:23275061]