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Compound class: Synthetic organic
Comment: SC83288 is an amicarbalide derivative and the clinical development candidate for this novel antimalarial chemotype .
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
|Guide to Malaria Pharmacology Comments|
|SC83288 has a different mechanism of action and no cross resistance to the artemisinin class of antimalarial compounds , supporting the clinical development of SC83288 as alternative treatment for severe malaria in areas affected by artemisinin-resistance.
Potential Target/Mechanism Of Action: As the precise mechanism of action of SC83288 is not yet known, we do not have a molecular target for this compound.