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Compound class: Synthetic organic
Comment: SC83288 is an amicarbalide derivative and the clinical development candidate for this novel antimalarial chemotype .
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
1. Duffey M, Sanchez CP, Lanzer M. (2018)
Profiling of the anti-malarial drug candidate SC83288 against artemisinins in Plasmodium falciparum.
Malar J, 17 (1): 121. [PMID:29558913]
2. Pegoraro S, Duffey M, Otto TD, Wang Y, Rösemann R, Baumgartner R, Fehler SK, Lucantoni L, Avery VM, Moreno-Sabater A et al.. (2017)
SC83288 is a clinical development candidate for the treatment of severe malaria.
Nat Commun, 8: 14193. [PMID:28139658]