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Synonyms: GNF-Pf-506 | Qualaquin® | Quinate® | quinine bisulphate | quinine sulfate
quinine is an approved drug (FDA (2005, as quinine sulfate, previous history unspecified))
Compound class: Natural product or derivative
Comment: First extracted from the bark of the cinchona tree and used as an antimalarial medicine, quinine has also been synthesized in the laboratory .
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Guide to Malaria Pharmacology Comments|
|Quinine is listed in the World Health Organisation's 21st Essential Medicines List (2019) for use in the management of severe P. falciparum malaria (as a combination therapy with doxycycline).|