- Advanced search
- Immuno Portal
- Malaria Portal
Synonyms: 3-hydroxymethylindole | 3-indolemethanol | 3-indolylcarbinol | I3C
Compound class: Synthetic organic
Comment: Indole-3-carbinol (I3C) is a secondary plant metabolite produced in Brassica family vegetables. It has been reported as an aryl hydrocarbon receptor agonist, although its affinity is very low and it therefore may not be a significant agonist of the AhR in vivo . Anticarcinogenic and antitumourigenic properties of I3C have been reported in various types of cancer cells [1,3-4].
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Aggarwal BB, Ichikawa H. (2005)
Molecular targets and anticancer potential of indole-3-carbinol and its derivatives.
Cell Cycle, 4 (9): 1201-15. [PMID:16082211]
2. Bjeldanes LF, Kim JY, Grose KR, Bartholomew JC, Bradfield CA. (1991)
Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Proc Natl Acad Sci USA, 88 (21): 9543-7. [PMID:1658785]
3. Metidji A, Omenetti S, Crotta S, Li Y, Nye E, Ross E, Li V, Maradana MR, Schiering C, Stockinger B. (2018)
The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity.
Immunity, 49 (2): 353-362.e5. DOI: 10.1016/j.immuni.2018.07.010 [PMID:30119997]
4. Rogan EG. (2006)
The natural chemopreventive compound indole-3-carbinol: state of the science.
In Vivo, 20 (2): 221-8. [PMID:16634522]