indole-3-carbinol   Click here for help

GtoPdb Ligand ID: 10047

Synonyms: 3-hydroxymethylindole | 3-indolemethanol | 3-indolylcarbinol | I3C
PDB Ligand Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Indole-3-carbinol (I3C) is a secondary plant metabolite produced in Brassica family vegetables. It has been reported as an aryl hydrocarbon receptor agonist, although its affinity is very low and it therefore may not be a significant agonist of the AhR in vivo [2]. Anticarcinogenic and antitumourigenic properties of I3C have been reported in various types of cancer cells [1,3-4].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 1
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 36.02
Molecular weight 147.07
XLogP 1.75
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OCc1c[nH]c2c1cccc2
Isomeric SMILES OCc1c[nH]c2c1cccc2
InChI InChI=1S/C9H9NO/c11-6-7-5-10-9-4-2-1-3-8(7)9/h1-5,10-11H,6H2
InChI Key IVYPNXXAYMYVSP-UHFFFAOYSA-N
References
1. Aggarwal BB, Ichikawa H. (2005)
Molecular targets and anticancer potential of indole-3-carbinol and its derivatives.
Cell Cycle, 4 (9): 1201-15. [PMID:16082211]
2. Bjeldanes LF, Kim JY, Grose KR, Bartholomew JC, Bradfield CA. (1991)
Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Proc Natl Acad Sci USA, 88 (21): 9543-7. [PMID:1658785]
3. Metidji A, Omenetti S, Crotta S, Li Y, Nye E, Ross E, Li V, Maradana MR, Schiering C, Stockinger B. (2018)
The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity.
Immunity, 49 (2): 353-362.e5. DOI: 10.1016/j.immuni.2018.07.010 [PMID:30119997]
4. Rogan EG. (2006)
The natural chemopreventive compound indole-3-carbinol: state of the science.
In Vivo, 20 (2): 221-8. [PMID:16634522]