rupatadine   Click here for help

GtoPdb Ligand ID: 10103

Synonyms: Rinialer® | Rupafin® | UR-12592 [2] | UR12592
Approved drug Immunopharmacology Ligand
rupatadine is an approved drug (UK (2007))
Compound class: Synthetic organic
Comment: Rupatadine is a second generation histamine H1 receptor and platelet-activating factor (PAF) receptor antagonist [2,5]. It is selective, long-acting and non-sedating. It was designed as a single structure dual antagonist based on evidence that PAF appears to act alongside histamine in the pathogenesis of the allergic response.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 29.02
Molecular weight 415.18
XLogP 4.12
No. Lipinski's rules broken 0
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Canonical SMILES Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1
Isomeric SMILES Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1
InChI InChI=1S/C26H26ClN3/c1-18-13-19(16-28-15-18)17-30-11-8-20(9-12-30)25-24-7-6-23(27)14-22(24)5-4-21-3-2-10-29-26(21)25/h2-3,6-7,10,13-16H,4-5,8-9,11-12,17H2,1H3
1. Keam SJ, Plosker GL. (2007)
Rupatadine: a review of its use in the management of allergic disorders.
Drugs, 67 (3): 457-74. [PMID:17335300]
2. Merlos M, Giral M, Balsa D, Ferrando R, Queralt M, Puigdemont A, García-Rafanell J, Forn J. (1997)
Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF).
J Pharmacol Exp Ther, 280 (1): 114-21. [PMID:8996188]
3. Morphy R, Rankovic Z. (2005)
Designed multiple ligands. An emerging drug discovery paradigm.
J Med Chem, 48 (21): 6523-43. [PMID:16220969]
4. Mullol J, Bousquet J, Bachert C, Canonica WG, Gimenez-Arnau A, Kowalski ML, Martí-Guadaño E, Maurer M, Picado C, Scadding G et al.. (2008)
Rupatadine in allergic rhinitis and chronic urticaria.
Allergy, 63 Suppl 87: 5-28. [PMID:18339040]
5. Picado C. (2006)
Rupatadine: pharmacological profile and its use in the treatment of allergic disorders.
Expert Opin Pharmacother, 7 (14): 1989-2001. [PMID:17020424]