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Synonyms: Rinialer® | Rupafin® | UR-12592  | UR12592
rupatadine is an approved drug (UK (2007))
Compound class: Synthetic organic
Comment: Rupatadine is a second generation histamine H1 receptor and platelet-activating factor (PAF) receptor antagonist [2,5]. It is selective, long-acting and non-sedating. It was designed as a single structure dual antagonist based on evidence that PAF appears to act alongside histamine in the pathogenesis of the allergic response.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Keam SJ, Plosker GL. (2007)
Rupatadine: a review of its use in the management of allergic disorders.
Drugs, 67 (3): 457-74. [PMID:17335300]
2. Merlos M, Giral M, Balsa D, Ferrando R, Queralt M, Puigdemont A, García-Rafanell J, Forn J. (1997)
Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF).
J Pharmacol Exp Ther, 280 (1): 114-21. [PMID:8996188]
3. Morphy R, Rankovic Z. (2005)
Designed multiple ligands. An emerging drug discovery paradigm.
J Med Chem, 48 (21): 6523-43. [PMID:16220969]
4. Mullol J, Bousquet J, Bachert C, Canonica WG, Gimenez-Arnau A, Kowalski ML, Martí-Guadaño E, Maurer M, Picado C, Scadding G et al.. (2008)
Rupatadine in allergic rhinitis and chronic urticaria.
Allergy, 63 Suppl 87: 5-28. [PMID:18339040]
5. Picado C. (2006)
Rupatadine: pharmacological profile and its use in the treatment of allergic disorders.
Expert Opin Pharmacother, 7 (14): 1989-2001. [PMID:17020424]