Audien   Click here for help

GtoPdb Ligand ID: 10189

Compound class: Inorganic
Comment: Audien is a gold (Au)-containing compound that was designed as a potential antitumor agent [2]. In this reference it is described as Au(dien)Cl]Cl2, where dien = diethylentriamine. It has been shown to act as an inhibitor of aquaglyceroporin AQP3 [1].
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1. Martins AP, Marrone A, Ciancetta A, Galán Cobo A, Echevarría M, Moura TF, Re N, Casini A, Soveral G. (2012)
Targeting aquaporin function: potent inhibition of aquaglyceroporin-3 by a gold-based compound.
PLoS ONE, 7 (5): e37435. [PMID:22624030]
2. Messori L, Abbate F, Marcon G, Orioli P, Fontani M, Mini E, Mazzei T, Carotti S, O'Connell T, Zanello P. (2000)
Gold(III) complexes as potential antitumor agents: solution chemistry and cytotoxic properties of some selected gold(III) compounds.
J Med Chem, 43 (19): 3541-8. [PMID:11000008]