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Synonyms: compound 46  | DO-264
Compound class: Synthetic organic
Comment: DO264 is a selective inhibitor of the serine hydrolase, ABHD12 [2-3]. It produces immunostimulatory effects in vitro and in vivo, and is suitable as a tool compound to investigate the biological functions of ABHD12 [1,4].
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Kind L, Kursula P. (2019)
Structural properties and role of the endocannabinoid lipases ABHD6 and ABHD12 in lipid signalling and disease.
Amino Acids, 51 (2): 151-174. [PMID:30564946]
2. Ogasawara D, Ichu TA, Jing H, Hulce JJ, Reed A, Ulanovskaya OA, Cravatt BF. (2019)
Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase α/β-Hydrolase Domain-Containing 12 (ABHD12).
J. Med. Chem., 62 (3): 1643-1656. [PMID:30720278]
3. Ogasawara D, Ichu TA, Vartabedian VF, Benthuysen J, Jing H, Reed A, Ulanovskaya OA, Hulce JJ, Roberts A, Brown S et al.. (2018)
Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo.
Nat. Chem. Biol., 14 (12): 1099-1108. [PMID:30420694]
4. Savinainen JR, Navia-Paldanius D, Laitinen JT. (2016)
A Sensitive and Versatile Fluorescent Activity Assay for ABHD12.
Methods Mol. Biol., 1412: 179-89. [PMID:27245904]