GSK1702934A   Click here for help

GtoPdb Ligand ID: 10278

Compound class: Synthetic organic
Comment: GSK1702934A acts as a TRPC3/TRPC6 channel activator/agonist [2] (structure obtained from [1]).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 86.34
Molecular weight 395.17
XLogP 2.74
No. Lipinski's rules broken 0
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Canonical SMILES O=C(c1cc2c(s1)CCCCC2)N1CCC(CC1)n1c(=O)[nH]c2c1cccc2
Isomeric SMILES O=C(c1cc2c(s1)CCCCC2)N1CCC(CC1)n1c(=O)[nH]c2c1cccc2
InChI InChI=1S/C22H25N3O2S/c26-21(20-14-15-6-2-1-3-9-19(15)28-20)24-12-10-16(11-13-24)25-18-8-5-4-7-17(18)23-22(25)27/h4-5,7-8,14,16H,1-3,6,9-13H2,(H,23,27)
1. Doleschal B, Primessnig U, Wölkart G, Wolf S, Schernthaner M, Lichtenegger M, Glasnov TN, Kappe CO, Mayer B, Antoons G et al.. (2015)
TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1.
Cardiovasc Res, 106 (1): 163-73. [PMID:25631581]
2. Xu X, Lozinskaya I, Costell M, Lin Z, Ball JA, Bernard R, Behm DJ, Marino JP, Schnackenberg CG. (2013)
Characterization of Small Molecule TRPC3 and TRPC6 agonist and Antagonists.
Biophys J, 104 (2): 454a Meeting abstract. DOI: 10.1016/j.bpj.2012.11.2513