GSK1702934A   Click here for help

GtoPdb Ligand ID: 10278

Compound class: Synthetic organic
Comment: GSK1702934A acts as a TRPC3/TRPC6 channel activator/agonist [2] (structure obtained from [1]).
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 86.34
Molecular weight 395.17
XLogP 2.74
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES O=C(c1cc2c(s1)CCCCC2)N1CCC(CC1)n1c(=O)[nH]c2c1cccc2
Isomeric SMILES O=C(c1cc2c(s1)CCCCC2)N1CCC(CC1)n1c(=O)[nH]c2c1cccc2
InChI InChI=1S/C22H25N3O2S/c26-21(20-14-15-6-2-1-3-9-19(15)28-20)24-12-10-16(11-13-24)25-18-8-5-4-7-17(18)23-22(25)27/h4-5,7-8,14,16H,1-3,6,9-13H2,(H,23,27)
Bioactivity Comments
Note that the EC50 data presented here is from a meeting abstract [2].
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
TRPC3 Hs Activator Agonist 7.1 pEC50 - 2
pEC50 7.1 (EC50 8x10-8 M) [2]
Description: Activation of hTRPC3-mediated currents in HEK293 cells in whole-cell patch-clamp experiments.
TRPC6 Hs Activator Agonist 6.4 pIC50 - 2
pIC50 6.4 (IC50 4.4x10-7 M) [2]
Description: Activation of TRPC6-mediated currents in HEK293 cells in whole-cell patch-clamp experiments.