CIM0216   Click here for help

GtoPdb Ligand ID: 10297

Synonyms: CIM-0216
Compound class: Synthetic organic
Comment: CIM0216 is a synthetic TRPM3 ion channel activator [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 53.93
Molecular weight 349.18
XLogP 4.09
No. Lipinski's rules broken 0
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Canonical SMILES CC1ON=C(C1)NC(=O)C(N1CCCc2c1cccc2)c1ccccc1
Isomeric SMILES CC1ON=C(C1)NC(=O)C(N1CCCc2c1cccc2)c1ccccc1
InChI InChI=1S/C21H23N3O2/c1-15-14-19(23-26-15)22-21(25)20(17-9-3-2-4-10-17)24-13-7-11-16-8-5-6-12-18(16)24/h2-6,8-10,12,15,20H,7,11,13-14H2,1H3,(H,22,23,25)
1. Held K, Kichko T, De Clercq K, Klaassen H, Van Bree R, Vanherck JC, Marchand A, Reeh PW, Chaltin P, Voets T et al.. (2015)
Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release.
Proc Natl Acad Sci USA, 112 (11): E1363-72. [PMID:25733887]
2. Thiel G, Rubil S, Lesch A, Guethlein LA, Rössler OG. (2017)
Transient receptor potential TRPM3 channels: Pharmacology, signaling, and biological functions.
Pharmacol Res, 124: 92-99. [PMID:28720517]