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Synonyms: loxicodegol (deleted INN) | NKTR-181 | NKTR181
Compound class: Synthetic organic
Comment: Oxycodegol (NKTR-181; Nektar Therapeutics) is a μ-opioid receptor agonist analgesic . It was designed to enter the brain slowly, so as to reduce CNS-mediated side effects and abuse potential.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Gudin J, Rauck R, Argoff C, Agaiby E, Gimbel J, Katz N, Doberstein SK, Tagliaferri M, Tagliaferri M, Potts J et al.. (2020)
Long-term Safety and Tolerability of NKTR-181 in Patients with Moderate to Severe Chronic Low Back Pain or Chronic Noncancer Pain: A Phase 3 Multicenter, Open-Label, 52-Week Study (SUMMIT-08 LTS).
Pain Med, 21 (7): 1347-1356. [PMID:31361019]
2. Lanier RK, Henningfield JE, Gudin J, Rauck R, Elder H, Erpelding N, Treister R, Gimbel J, Tagliaferri M, Doberstein SK et al.. (2019)
Assessment of potentially abuse-related events in two phase 3 studies of NKTR-181, a novel opioid analgesic, using the MADDERS® system (Misuse, Abuse, and Diversion Drug Event Reporting System).
Curr Med Res Opin, 35 (9): 1513-1522. [PMID:30932719]
3. Miyazaki T, Choi IY, Rubas W, Anand NK, Ali C, Evans J, Gursahani H, Hennessy M, Kim G, McWeeney D et al.. (2017)
NKTR-181: A Novel Mu-Opioid Analgesic with Inherently Low Abuse Potential.
J Pharmacol Exp Ther, 363 (1): 104-113. [PMID:28778859]