Synonyms: ACT-179811 | ACT179811
Compound class:
Synthetic organic
Comment: Cadazolid (ACT-179811) is a quinolonyl-oxazolidinone (quinoxolidinone) antibacterial with Gram-positive activity. It targets the bacterial protein synthesis machinery by binding to the peptidyl transferase centre (PTC) of the ribosome [1].
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References |
1. Boucek MM, Snyderman R. (1976)
Calcium influx requirement for human neutrophil chemotaxis: inhibition by lanthanum chloride. Science, 193 (4256): 905-7. [PMID:948752] |
2. Gerding DN, Cornely OA, Grill S, Kracker H, Marrast AC, Nord CE, Talbot GH, Buitrago M, Gheorghe Diaconescu I, Murta de Oliveira C et al.. (2019)
Cadazolid for the treatment of Clostridium difficile infection: results of two double-blind, placebo-controlled, non-inferiority, randomised phase 3 trials. Lancet Infect Dis, 19 (3): 265-274. [PMID:30709665] |