cadazolid   Click here for help

GtoPdb Ligand ID: 10767

Synonyms: ACT-179811 | ACT179811
PDB Ligand
Compound class: Synthetic organic
Comment: Cadazolid (ACT-179811) is a quinolonyl-oxazolidinone (quinoxolidinone) antibacterial with Gram-positive activity. It targets the bacterial protein synthesis machinery by binding to the peptidyl transferase centre (PTC) of the ribosome [1].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 141.77
Molecular weight 585.19
XLogP 4.84
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OC[C@@H]1OC(=O)N(C1)c1ccc(c(c1)F)OCC1(O)CCN(CC1)c1cc2c(cc1F)c(=O)c(cn2C1CC1)C(=O)O
Isomeric SMILES OC[C@@H]1OC(=O)N(C1)c1ccc(c(c1)F)OCC1(O)CCN(CC1)c1cc2c(cc1F)c(=O)c(cn2C1CC1)C(=O)O
InChI InChI=1S/C29H29F2N3O8/c30-21-10-19-23(33(16-1-2-16)13-20(26(19)36)27(37)38)11-24(21)32-7-5-29(40,6-8-32)15-41-25-4-3-17(9-22(25)31)34-12-18(14-35)42-28(34)39/h3-4,9-11,13,16,18,35,40H,1-2,5-8,12,14-15H2,(H,37,38)/t18-/m1/s1
InChI Key XWFCFMXQTBGXQW-GOSISDBHSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
1-cyclopropyl-6-fluoro-7-[4-[[2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenoxy]methyl]-4-hydroxypiperidin-1-yl]-4-oxoquinoline-3-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
9377 cadazolid
Synonyms Click here for help
ACT-179811 | ACT179811
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Cadazolid
Other databases
CAS Registry No. 1025097-10-2 (source: WHO INN record)
ChEMBL Ligand CHEMBL3707376
GtoPdb PubChem SID 405560208
PubChem CID 44242317
RCSB PDB Ligand JJH
Search Google for chemical match using the InChIKey XWFCFMXQTBGXQW-GOSISDBHSA-N
Search Google for chemicals with the same backbone XWFCFMXQTBGXQW
Search PubMed clinical trials cadazolid
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UniChem Compound Search for chemical match using the InChIKey XWFCFMXQTBGXQW-GOSISDBHSA-N
UniChem Connectivity Search for chemical match using the InChIKey XWFCFMXQTBGXQW-GOSISDBHSA-N