cefluprenam   Click here for help

GtoPdb Ligand ID: 10777

Synonyms: E-1077 | E1077
Compound class: Synthetic organic
Comment: Cefluprenam (E-1077) is a parenteral cephalosporin antibacterial [2-3]. It exhibits broad in vitro antibacterial activity against gram-positive and gram-negative bacteria.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 11
Hydrogen bond donors 3
Rotatable bonds 13
Topological polar surface area 259.56
Molecular weight 556.13
XLogP -4.07
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES FCO/N=C(/c1nsc(n1)N)\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)[O-])/C=C/C[N+](CC(=O)N)(CC)C
Isomeric SMILES FCO/N=C(/c1nsc(n1)N)\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)[O-])/C=C/C[N+](CC(=O)N)(CC)C
InChI InChI=1S/C20H25FN8O6S2/c1-3-29(2,7-11(22)30)6-4-5-10-8-36-18-13(17(32)28(18)14(10)19(33)34)24-16(31)12(26-35-9-21)15-25-20(23)37-27-15/h4-5,13,18H,3,6-9H2,1-2H3,(H5-,22,23,24,25,27,30,31,33,34)/b5-4+,26-12-/t13-,18-,29?/m1/s1
InChI Key XAKKNLNAJBNLPC-MAYKBZFQSA-N
References
1. Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V. (2000)
beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter.
J Biol Chem, 275 (3): 1699-707. [PMID:10636865]
2. Toyosawa T, Miyazaki S, Tsuji A, Yamaguchi K, Goto S. (1993)
In vitro and in vivo antibacterial activities of E1077, a novel parenteral cephalosporin.
Antimicrob Agents Chemother, 37 (1): 60-6. [PMID:8431019]
3. Watanabe N, Hiruma R, Katsu K. (1992)
In vitro evaluation of E1077, a new cephalosporin with a broad antibacterial spectrum.
Antimicrob Agents Chemother, 36 (3): 589-97. [PMID:1622167]