Synonyms: Artrodar® | Fisiodar®
diacerein is an approved drug
Compound class:
Synthetic organic
Comment: Diacerein is a prodrug which is metabolized to rhein. It has anti-inflammatory activity via antagonism of the interleukin-1 receptor. It is an anthraquinone type compound and growth-inhibitory effects of diacerein have been shown against various drug-resistant staphylococcal strains [2].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. EMA.
EU/3/19/2161. Accessed on 01/05/2020. Modified on 01/05/2020. European Medicines Agency, https://www.ema.europa.eu/en/medicines/human/orphan-designations/eu3192161 |
2. Zhang H, Liu S, Yue J, Sun S, Lv Q, Jian S, Xie Y, Han L, Zhang F, Dai Y et al.. (2019)
In Vitro Antimicrobial Activity of Diacerein on 76 Isolates of Gram-Positive Cocci from Bacterial Keratitis Patients and In Vivo Study of Diacerein Eye Drops on Staphylococcus aureus Keratitis in Mice. Antimicrob Agents Chemother, 63 (4). DOI: 10.1128/AAC.01874-18 [PMID:30718254] |