Synonyms: CP-14,445 | CP-14445
oxantel is an approved drug
Compound class:
Synthetic organic
Comment: Oxantel is an anthelmintic agent. In addition, it inhibits fumarate reductase, an enzyme that is crucial for the survival of pathogenic bacteria in the biofilm in periodontal pockets. It has been suggested that oxantel might guard against chronic periodontitis, but efficacy of this potential antibacterial function is yet to be confirmed [1-2].
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References |
1. Dashper S, O'Brien-Simpson N, Liu SW, Paolini R, Mitchell H, Walsh K, D'Cruze T, Hoffmann B, Catmull D, Zhu Y et al.. (2014)
Oxantel disrupts polymicrobial biofilm development of periodontal pathogens. Antimicrob Agents Chemother, 58 (1): 378-85. [PMID:24165189] |
2. (2014)
Drug may guard against periodontitis. J Calif Dent Assoc, 42 (1): 14. [PMID:25080682] |