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Synonyms: compound 34 [PMID: 27570890] | TUG1197
Compound class: Synthetic organic
Comment: TUG-1197 is a selective agonist of free fatty acid receptor 4 (FFAR4) [1-2].
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Azevedo CM, Watterson KR, Wargent ET, Hansen SV, Hudson BD, Kępczyńska MA, Dunlop J, Shimpukade B, Christiansen E, Milligan G et al.. (2016)
Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity.
J Med Chem, 59 (19): 8868-8878. [PMID:27570890]
2. Watterson KR, Hansen SVF, Hudson BD, Alvarez-Curto E, Raihan SZ, Azevedo CMG, Martin G, Dunlop J, Yarwood SJ, Ulven T et al.. (2017)
Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4.
Mol Pharmacol, 91 (6): 630-641. [PMID:28385906]