exendin-4   Click here for help

GtoPdb Ligand ID: 1135

Synonyms: AC 2993 | AC002993 | AC2993A | Bydureon® | Byetta®
Approved drug
exendin-4 is an approved drug (FDA (2005), EMA (2006))
Comment: This peptide is found in the venom of the Gila monster Heloderma suspectum. Exenatide is the synthetic form of the peptide used in clinical practice. Exendin-4 is a GLP-1 analogue/mimetic [1]. There is some ambiguity surrounding the exact stereochemistry of exendin-4. Representations of the peptide's full chemical structure can be accessed using the PubChem, ChEMBL and ChEBI links that we provide in the Database Links table.
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View more information in the IUPHAR Pharmacology Education Project: exenatide

1. Bond A. (2006)
Exenatide (Byetta) as a novel treatment option for type 2 diabetes mellitus.
Proc (Bayl Univ Med Cent), 19 (3): 281-4. [PMID:17252050]
2. Jorgensen R, Martini L, Schwartz TW, Elling CE. (2005)
Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype.
Mol Endocrinol, 19 (3): 812-23. [PMID:15528268]
3. Miranda LP, Winters KA, Gegg CV, Patel A, Aral J, Long J, Zhang J, Diamond S, Guido M, Stanislaus S et al.. (2008)
Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity.
J Med Chem, 51 (9): 2758-65. [PMID:18412318]